The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson's disease. [electronic resource]
Producer: 20171219Description: 53 p. digitalISSN:- 2051-5960
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
- Animals
- Antiparkinson Agents -- pharmacology
- Cation Transport Proteins -- metabolism
- Cell Line, Tumor
- Dogs
- Female
- Humans
- Iron -- metabolism
- Male
- Mice, Inbred C57BL
- Mice, Transgenic
- Neurons -- drug effects
- Neuroprotective Agents -- pharmacology
- Oxidative Stress -- drug effects
- Oxidopamine
- Parkinsonian Disorders -- drug therapy
- Quinazolinones -- pharmacology
- Rats
- Recombinant Proteins -- genetics
- Substantia Nigra -- drug effects
- alpha-Synuclein -- genetics
- Ferroportin
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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