Obacunone causes sustained expression of MKP-1 thus inactivating p38 MAPK to suppress pro-inflammatory mediators through intracellular MIF. [electronic resource]
Producer: 20180706Description: 837-849 p. digitalISSN:- 1097-4644
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Benzoxepins -- pharmacology
- Chemokine CCL2 -- metabolism
- Dual Specificity Phosphatase 1 -- genetics
- Gene Expression Regulation -- drug effects
- Interleukins -- metabolism
- Intramolecular Oxidoreductases -- genetics
- Limonins -- pharmacology
- Lipopolysaccharides -- adverse effects
- Macrophage Migration-Inhibitory Factors -- genetics
- Macrophages -- cytology
- Mice
- Mice, Inbred BALB C
- Nitric Oxide -- metabolism
- RAW 264.7 Cells
- Transcription Factor AP-1 -- metabolism
- p38 Mitogen-Activated Protein Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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