BRAF-inhibitor Associated MEK Mutations Increase RAF-Dependent and -Independent Enzymatic Activity. [electronic resource]
Producer: 20180618Description: 1431-1444 p. digitalISSN:- 1557-3125
- Allosteric Site
- Cell Line, Tumor
- Cell Proliferation
- Colorectal Neoplasms -- drug therapy
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- MAP Kinase Kinase 1 -- chemistry
- MAP Kinase Kinase 2 -- chemistry
- MAP Kinase Signaling System -- drug effects
- Models, Molecular
- Mutation
- Phosphorylation
- Protein Kinase Inhibitors -- pharmacology
- Protein Structure, Secondary
- Proto-Oncogene Proteins B-raf -- chemistry
- raf Kinases -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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