Suppression of Akt1-β-catenin pathway in advanced prostate cancer promotes TGFβ1-mediated epithelial to mesenchymal transition and metastasis. [electronic resource]
Producer: 20170926Description: 177-189 p. digitalISSN:- 1872-7980
- Adenocarcinoma -- drug therapy
- Animals
- Antineoplastic Agents -- therapeutic use
- Cell Line, Tumor
- Cell Movement -- drug effects
- Down-Regulation
- Epithelial-Mesenchymal Transition -- drug effects
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Nude
- Phenotype
- Prostatic Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- therapeutic use
- Protein Serine-Threonine Kinases -- metabolism
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- RNA Interference
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta -- metabolism
- Signal Transduction
- Time Factors
- Transfection
- Transforming Growth Factor beta1 -- metabolism
- Xenograft Model Antitumor Assays
- beta Catenin -- antagonists & inhibitors
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Publication Type: Journal Article
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