The small molecule inhibitor YK-4-279 disrupts mitotic progression of neuroblastoma cells, overcomes drug resistance and synergizes with inhibitors of mitosis. [electronic resource]
Producer: 20170926Description: 74-85 p. digitalISSN:- 1872-7980
- Antimitotic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Aurora Kinase A -- antagonists & inhibitors
- Azepines -- pharmacology
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Dose-Response Relationship, Drug
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Drug Synergism
- Humans
- Indoles -- pharmacology
- Inhibitory Concentration 50
- Kinetochores -- drug effects
- Mitosis -- drug effects
- Neuroblastoma -- drug therapy
- Paclitaxel -- pharmacology
- Prometaphase -- drug effects
- Protein Kinase Inhibitors -- pharmacology
- Pyrimidines -- pharmacology
- RNA Interference
- Signal Transduction -- drug effects
- Spindle Apparatus -- drug effects
- Time Factors
- Transfection
- Tumor Suppressor Protein p53 -- genetics
- Vincristine -- pharmacology
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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