A dual agonist of farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5, INT-767, reverses age-related kidney disease in mice. [electronic resource]
Producer: 20170808Description: 12018-12024 p. digitalISSN:- 1083-351X
- Aging
- Animals
- Anti-Inflammatory Agents, Non-Steroidal -- pharmacology
- Bile Acids and Salts -- pharmacology
- Caloric Restriction
- Cells, Cultured
- Gene Expression Regulation, Developmental
- Humans
- Hypolipidemic Agents -- pharmacology
- Inflammation Mediators -- antagonists & inhibitors
- Kidney -- drug effects
- Longevity
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mitochondria -- enzymology
- Mitochondrial Turnover
- Podocytes -- drug effects
- Receptors, Cytoplasmic and Nuclear -- agonists
- Receptors, G-Protein-Coupled -- agonists
- Renal Insufficiency -- drug therapy
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Publication Type: Journal Article
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