TIMELESS confers cisplatin resistance in nasopharyngeal carcinoma by activating the Wnt/β-catenin signaling pathway and promoting the epithelial mesenchymal transition. [electronic resource]
Producer: 20170926Description: 117-130 p. digitalISSN:- 1872-7980
- Adult
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Biomarkers, Tumor -- genetics
- Carcinoma -- drug therapy
- Cell Cycle Proteins -- genetics
- Cell Line, Tumor
- Cisplatin -- pharmacology
- Disease-Free Survival
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Epithelial-Mesenchymal Transition -- drug effects
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Intracellular Signaling Peptides and Proteins -- genetics
- Kaplan-Meier Estimate
- Male
- Mice, Inbred BALB C
- Mice, Nude
- Middle Aged
- Nasopharyngeal Carcinoma
- Nasopharyngeal Neoplasms -- drug therapy
- Neoplasm Grading
- Neoplasm Staging
- Phenotype
- Proportional Hazards Models
- RNA Interference
- Time Factors
- Transcription, Genetic
- Transfection
- Wnt Signaling Pathway -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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