Select human cancer mutants of NRMT1 alter its catalytic activity and decrease N-terminal trimethylation. [electronic resource]
Producer: 20170824Description: 1639-1652 p. digitalISSN:- 1469-896X
- A549 Cells
- Amino Acid Substitution
- Biocatalysis
- Catalytic Domain
- Cell Cycle Proteins -- chemistry
- Crystallography, X-Ray
- Endometrial Neoplasms -- enzymology
- Female
- Gene Expression
- Guanine Nucleotide Exchange Factors -- chemistry
- HCT116 Cells
- HEK293 Cells
- Histidine -- genetics
- Humans
- Isoenzymes -- chemistry
- Kinetics
- Lung Neoplasms -- enzymology
- Male
- Methylation
- Methyltransferases -- chemistry
- Models, Molecular
- Mutation
- Neoplasm Proteins -- chemistry
- Nuclear Proteins -- chemistry
- Oligopeptides -- genetics
- Protein Conformation, alpha-Helical
- Protein Conformation, beta-Strand
- Protein Interaction Domains and Motifs
- Recombinant Fusion Proteins -- chemistry
- Substrate Specificity
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Publication Type: Journal Article
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