Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex. [electronic resource]
Producer: 20181211Description: 15522 p. digitalISSN:- 2041-1723
- Adenosine -- chemistry
- Alternative Splicing
- Carrier Proteins -- chemistry
- Cell Proliferation
- Cell Survival
- Cryoelectron Microscopy
- Crystallography, X-Ray
- Epoxy Compounds -- chemistry
- Exons
- Fatty Alcohols -- chemistry
- HCT116 Cells
- Humans
- Introns
- Macrolides -- chemistry
- Mass Spectrometry
- Mutagenesis, Site-Directed
- Mutation
- Myeloid Cell Leukemia Sequence 1 Protein -- chemistry
- Phosphoproteins -- chemistry
- Protein Binding
- Protein Conformation
- Pyrans -- chemistry
- RNA Interference
- RNA Splicing Factors -- chemistry
- RNA-Binding Proteins
- Recombinant Proteins -- chemistry
- Sequence Analysis, RNA
- Spiro Compounds -- chemistry
- Spliceosomes -- metabolism
- Trans-Activators
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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