Matriptase Induction of Metalloproteinase-Dependent Aggrecanolysis In Vitro and In Vivo: Promotion of Osteoarthritic Cartilage Damage by Multiple Mechanisms. [electronic resource]
Producer: 20170821Description: 1601-1611 p. digitalISSN:- 2326-5205
- ADAMTS4 Protein -- drug effects
- ADAMTS5 Protein -- drug effects
- Aged
- Aged, 80 and over
- Aggrecans -- drug effects
- Animals
- Antibodies, Neutralizing -- pharmacology
- Blotting, Western
- Cartilage, Articular -- drug effects
- Endopeptidases -- drug effects
- Female
- Gene Expression Profiling
- Humans
- Immunohistochemistry
- In Vitro Techniques
- Low Density Lipoprotein Receptor-Related Protein-1 -- drug effects
- Male
- Matrix Metalloproteinases -- drug effects
- Membrane Proteins -- antagonists & inhibitors
- Menisci, Tibial -- surgery
- Mice
- Middle Aged
- Osteoarthritis, Knee -- metabolism
- Real-Time Polymerase Chain Reaction
- Recombinant Proteins -- pharmacology
- Serine Endopeptidases -- metabolism
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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