Ponatinib promotes a G1 cell-cycle arrest of merlin/NF2-deficient human schwann cells. [electronic resource]
Producer: 20180326Description: 31666-31681 p. digitalISSN:- 1949-2553
- Antineoplastic Agents -- pharmacology
- Cell Line, Tumor
- Cell Survival -- drug effects
- Cyclin D1 -- metabolism
- Cyclin-Dependent Kinase Inhibitor p27 -- metabolism
- Focal Adhesion Protein-Tyrosine Kinases -- metabolism
- G1 Phase Cell Cycle Checkpoints -- drug effects
- Humans
- Imidazoles -- pharmacology
- MAP Kinase Signaling System -- drug effects
- Neurilemmoma -- genetics
- Neurofibromin 2 -- deficiency
- Paxillin -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Pyridazines -- pharmacology
- Receptors, Platelet-Derived Growth Factor -- metabolism
- STAT3 Transcription Factor -- metabolism
- Schwann Cells -- drug effects
- Signal Transduction -- drug effects
- src-Family Kinases -- metabolism
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Publication Type: Journal Article
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