Tyrosine 842 in the activation loop is required for full transformation by the oncogenic mutant FLT3-ITD. [electronic resource]
Producer: 20170828Description: 2679-2688 p. digitalISSN:- 1420-9071
- Animals
- Apoptosis
- Cell Line
- Cell Proliferation
- Cell Transformation, Neoplastic -- metabolism
- Down-Regulation
- Enzyme Activation
- Extracellular Signal-Regulated MAP Kinases -- metabolism
- Gene Duplication
- Humans
- Male
- Mice, Inbred BALB C
- Mutant Proteins -- metabolism
- Mutation -- genetics
- Myeloid Cells -- metabolism
- Oncogenes
- Phosphorylation
- Protein Stability
- Protein Tyrosine Phosphatase, Non-Receptor Type 11 -- metabolism
- Proteolysis
- Signal Transduction
- Tyrosine -- metabolism
- Ubiquitination
- fms-Like Tyrosine Kinase 3 -- chemistry
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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