Inhibition of phosphodiesterase 4 (PDE4) reduces dermal fibrosis by interfering with the release of interleukin-6 from M2 macrophages. [electronic resource]
Producer: 20170814Description: 1133-1141 p. digitalISSN:- 1468-2060
- Animals
- Bleomycin
- Cell Differentiation -- drug effects
- Collagen -- metabolism
- Cyclic Nucleotide Phosphodiesterases, Type 4 -- metabolism
- Cytokines -- genetics
- DNA Topoisomerases, Type I -- immunology
- Disease Models, Animal
- Fibroblasts -- drug effects
- Fibrosis
- Gene Expression -- drug effects
- Graft vs Host Disease -- complications
- Humans
- Interleukin-13 -- genetics
- Interleukin-6 -- genetics
- Macrophages -- drug effects
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Phosphodiesterase 4 Inhibitors -- pharmacology
- RNA, Messenger -- metabolism
- Rolipram -- pharmacology
- Scleroderma, Systemic -- drug therapy
- Skin -- drug effects
- Thalidomide -- analogs & derivatives
- Transforming Growth Factor beta1 -- genetics
- Transforming Growth Factor beta2 -- genetics
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Publication Type: Journal Article
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