Repositioning of amprenavir as a novel extracellular signal-regulated kinase-2 inhibitor and apoptosis inducer in MCF-7 human breast cancer. [electronic resource]
Producer: 20170613Description: 823-834 p. digitalISSN:- 1791-2423
- Animals
- Antineoplastic Agents -- therapeutic use
- Apoptosis -- drug effects
- Bcl-2-Like Protein 11 -- genetics
- Breast Neoplasms -- drug therapy
- Carbamates -- therapeutic use
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Drug Repositioning -- methods
- Female
- Furans
- HIV Protease Inhibitors -- therapeutic use
- Humans
- MCF-7 Cells
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Nude
- Mitogen-Activated Protein Kinase 1 -- antagonists & inhibitors
- Molecular Docking Simulation
- Molecular Dynamics Simulation
- Phosphorylation -- drug effects
- RNA Interference
- RNA, Small Interfering -- genetics
- Signal Transduction -- drug effects
- Sulfonamides -- therapeutic use
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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