ITD mutation in FLT3 tyrosine kinase promotes Warburg effect and renders therapeutic sensitivity to glycolytic inhibition. [electronic resource]
Producer: 20171024Description: 2143-2150 p. digitalISSN:- 1476-5551
- Adenosine Triphosphate -- metabolism
- Animals
- Antineoplastic Agents -- pharmacology
- Cell Line
- Cell Transformation, Neoplastic
- Deoxyglucose -- pharmacology
- Glycolysis -- drug effects
- Hematopoietic Stem Cells -- cytology
- Hexokinase -- biosynthesis
- Humans
- Hydrocarbons, Brominated -- pharmacology
- Leukemia, Experimental -- drug therapy
- Mice
- Mice, Inbred BALB C
- Microsatellite Repeats
- Mitochondria -- enzymology
- Molecular Targeted Therapy
- Neoplasm Proteins -- genetics
- Niacinamide -- analogs & derivatives
- Phenylurea Compounds -- pharmacology
- Propionates -- pharmacology
- Proto-Oncogene Proteins c-akt -- metabolism
- Sorafenib
- fms-Like Tyrosine Kinase 3 -- antagonists & inhibitors
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Publication Type: Journal Article
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