The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1. [electronic resource]
Producer: 20171020Description: 31 p. digitalISSN:- 1479-5876
- Aniline Compounds -- pharmacology
- Animals
- Anti-Inflammatory Agents -- pharmacology
- Arthritis, Experimental -- complications
- Arthritis, Rheumatoid -- drug therapy
- Cell Differentiation -- drug effects
- Crotonates
- Forkhead Transcription Factors -- metabolism
- Heme Oxygenase-1 -- metabolism
- Humans
- Hydroxybutyrates -- pharmacology
- Inflammation -- complications
- Isoxazoles -- metabolism
- Jurkat Cells
- Leflunomide
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- NF-E2-Related Factor 2 -- metabolism
- Nitric Oxide Synthase Type II -- metabolism
- Nitriles
- Oxidative Stress -- drug effects
- Signal Transduction -- drug effects
- Spleen -- pathology
- Th17 Cells -- cytology
- Toluidines
- Tyrosine -- analogs & derivatives
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Publication Type: Journal Article
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