Pathway level alterations rather than mutations in single genes predict response to HER2-targeted therapies in the neo-ALTTO trial. [electronic resource]
Producer: 20180501Description: 128-135 p. digitalISSN:- 1569-8041
- Antineoplastic Combined Chemotherapy Protocols -- therapeutic use
- Biopsy, Fine-Needle -- methods
- Breast Neoplasms -- drug therapy
- Class I Phosphatidylinositol 3-Kinases -- genetics
- DNA, Neoplasm -- genetics
- Female
- Humans
- Lapatinib
- Molecular Targeted Therapy
- Mutation
- Proportional Hazards Models
- Protein Kinase Inhibitors -- administration & dosage
- Quinazolines -- administration & dosage
- Receptor, ErbB-2 -- antagonists & inhibitors
- Trastuzumab -- administration & dosage
- Exome Sequencing
- rhoA GTP-Binding Protein -- genetics
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Publication Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
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