A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug-Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients. [electronic resource]
Producer: 20171229Description: 361-374 p. digitalISSN:- 1521-009X
- Adult
- Biphenyl Compounds -- administration & dosage
- Computer Simulation
- Cytochrome P-450 CYP3A -- metabolism
- Cytochrome P-450 CYP3A Inducers -- administration & dosage
- Cytochrome P-450 CYP3A Inhibitors -- administration & dosage
- Drug Interactions
- Female
- Healthy Volunteers
- Humans
- Ketoconazole -- administration & dosage
- Male
- Metabolic Clearance Rate
- Middle Aged
- Models, Biological
- Neoplasms -- drug therapy
- Pyridines -- administration & dosage
- Rifampin -- administration & dosage
- Smoothened Receptor -- antagonists & inhibitors
- Time Factors
- Young Adult
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Publication Type: Journal Article; Randomized Controlled Trial
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