Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage. [electronic resource]
Producer: 20180416Description: 1389-1394 p. digitalISSN:- 1091-6490
- Alzheimer Disease -- genetics
- Amyloid Precursor Protein Secretases -- antagonists & inhibitors
- Amyloid beta-Peptides -- metabolism
- Amyloid beta-Protein Precursor -- metabolism
- Animals
- Aspartic Acid Endopeptidases -- antagonists & inhibitors
- Brain -- drug effects
- Cell Line, Tumor
- Humans
- Imatinib Mesylate -- pharmacology
- Mice, Inbred C57BL
- Mice, Transgenic
- Peptide Fragments -- metabolism
- Protein Kinase Inhibitors -- pharmacology
- Proteolysis -- drug effects
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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