Enhancer Remodeling during Adaptive Bypass to MEK Inhibition Is Attenuated by Pharmacologic Targeting of the P-TEFb Complex. [electronic resource]
Producer: 20171219Description: 302-321 p. digitalISSN:- 2159-8290
- Animals
- Antineoplastic Agents -- pharmacology
- Azepines -- pharmacology
- Cell Cycle Proteins
- Cell Line, Tumor
- DNA Methylation
- Discoidin Domain Receptor 1 -- genetics
- Drug Resistance, Neoplasm
- Drug Synergism
- Enhancer Elements, Genetic
- Epigenesis, Genetic
- Female
- Heterocyclic Compounds, 4 or More Rings -- pharmacology
- Humans
- MAP Kinase Kinase 1 -- antagonists & inhibitors
- MAP Kinase Kinase 2 -- antagonists & inhibitors
- Mice, Inbred BALB C
- Mice, SCID
- Molecular Targeted Therapy
- Nuclear Proteins -- antagonists & inhibitors
- Positive Transcriptional Elongation Factor B -- antagonists & inhibitors
- Pyridones -- pharmacology
- Pyrimidinones -- pharmacology
- RNA Interference
- Transcription Factors -- antagonists & inhibitors
- Triazoles -- pharmacology
- Triple Negative Breast Neoplasms -- drug therapy
- Xenograft Model Antitumor Assays
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Publication Type: Clinical Trial; Journal Article
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