α-Synuclein binds and sequesters PIKE-L into Lewy bodies, triggering dopaminergic cell death via AMPK hyperactivation. [electronic resource]
Producer: 20180424Description: 1183-1188 p. digitalISSN:- 1091-6490
- 1-Methyl-4-phenylpyridinium -- toxicity
- Adenylate Kinase -- metabolism
- Aged
- Aged, 80 and over
- Animals
- Cell Death
- Dopaminergic Neurons -- metabolism
- Enzyme Activation
- GTP Phosphohydrolases -- deficiency
- GTP-Binding Proteins -- chemistry
- GTPase-Activating Proteins -- chemistry
- Humans
- Lewy Bodies -- metabolism
- MPTP Poisoning -- metabolism
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- Nerve Tissue Proteins -- deficiency
- Phosphorylation
- Pleckstrin Homology Domains
- Protein Aggregation, Pathological
- Protein Binding
- Protein Interaction Mapping
- Protein Processing, Post-Translational
- Proto-Oncogene Proteins c-fyn -- deficiency
- alpha-Synuclein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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