CDK4/6 or MAPK blockade enhances efficacy of EGFR inhibition in oesophageal squamous cell carcinoma. [electronic resource]
Producer: 20181109Description: 13897 p. digitalISSN:- 2041-1723
- Animals
- Carcinoma, Squamous Cell -- drug therapy
- Cell Line, Tumor
- Cyclin-Dependent Kinase 4 -- antagonists & inhibitors
- Cyclin-Dependent Kinase 6 -- antagonists & inhibitors
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Activation -- drug effects
- Epithelial-Mesenchymal Transition -- drug effects
- ErbB Receptors -- antagonists & inhibitors
- Erlotinib Hydrochloride -- pharmacology
- Esophageal Neoplasms -- drug therapy
- Esophageal Squamous Cell Carcinoma
- Gene Amplification
- Humans
- Mice
- Mitogen-Activated Protein Kinases -- antagonists & inhibitors
- Phenotype
- Protein Kinase Inhibitors -- pharmacology
- Treatment Outcome
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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