Improving potency and metabolic stability by introducing an alkenyl linker to pyridine-based histone deacetylase inhibitors for orally available RUNX3 modulators. [electronic resource]
Producer: 20170222Description: 997-1010 p. digitalISSN:- 1768-3254
- Acetylation
- Administration, Oral
- Animals
- Biological Availability
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Core Binding Factor Alpha 3 Subunit -- chemistry
- Drug Stability
- Female
- Histone Deacetylase Inhibitors -- chemistry
- Histone Deacetylases -- metabolism
- Humans
- Mice
- Microsomes -- metabolism
- Protein Stability -- drug effects
- Pyridines -- chemistry
- Structure-Activity Relationship
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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