Synthesis, characterization and antineoplastic activity of bis-aziridinyl dimeric naphthoquinone - A novel class of compounds with potent activity against acute myeloid leukemia cells. [electronic resource]
Producer: 20170627Description: 6-10 p. digitalISSN:- 1464-3405
- Animals
- Antineoplastic Agents -- chemical synthesis
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- DNA Breaks, Double-Stranded -- drug effects
- Dose-Response Relationship, Drug
- Drug Screening Assays, Antitumor
- Humans
- Leukemia, Myeloid, Acute -- drug therapy
- Mice
- Mice, Inbred NOD
- Molecular Structure
- Naphthoquinones -- chemical synthesis
- Neoplasms, Experimental -- drug therapy
- Reactive Oxygen Species -- metabolism
- Structure-Activity Relationship
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Publication Type: Journal Article; Research Support, N.I.H., Extramural
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