Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells. [electronic resource]
Producer: 20180221Description: 83907-83925 p. digitalISSN:- 1949-2553
- Acid Ceramidase -- antagonists & inhibitors
- Animals
- Antineoplastic Agents -- pharmacology
- Autophagy -- drug effects
- Cathepsin B -- metabolism
- Cathepsin D -- metabolism
- Cell Line, Tumor
- Ceramides -- metabolism
- Dose-Response Relationship, Drug
- Endoplasmic Reticulum Stress -- drug effects
- Enzyme Activation
- Enzyme Inhibitors -- pharmacology
- Lysosomes -- drug effects
- Mice, Inbred BALB C
- Myeloid-Derived Suppressor Cells -- drug effects
- Sarcoma -- drug therapy
- Signal Transduction -- drug effects
- Time Factors
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Publication Type: Journal Article
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