Doxorubicin anti-tumor mechanisms include Hsp60 post-translational modifications leading to the Hsp60/p53 complex dissociation and instauration of replicative senescence. [electronic resource]
Producer: 20170808Description: 75-86 p. digitalISSN:- 1872-7980
- Acetylation
- Antibiotics, Antineoplastic -- pharmacology
- Apoptosis -- drug effects
- Carcinoma, Mucoepidermoid -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cellular Senescence -- drug effects
- Chaperonin 60 -- genetics
- Chaperonins -- metabolism
- Cyclin-Dependent Kinase Inhibitor p21 -- metabolism
- Dose-Response Relationship, Drug
- Doxorubicin -- pharmacology
- G2 Phase Cell Cycle Checkpoints -- drug effects
- Histones -- metabolism
- Humans
- Lung Neoplasms -- drug therapy
- Mitochondrial Proteins -- genetics
- Protein Binding
- Protein Processing, Post-Translational -- drug effects
- Proteolysis
- Signal Transduction -- drug effects
- Tumor Suppressor Protein p53 -- metabolism
- Ubiquitination
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Publication Type: Journal Article
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