Preclinical efficacy of a RAF inhibitor that evades paradoxical MAPK pathway activation in protein kinase BRAF-mutant lung cancer. [electronic resource]
Producer: 20180330Description: 13456-13461 p. digitalISSN:- 1091-6490
- Animals
- Antineoplastic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Cell Line, Tumor
- Drug Resistance, Neoplasm -- drug effects
- Enzyme Activation -- drug effects
- Female
- Gene Knockdown Techniques
- Heterocyclic Compounds, 2-Ring -- adverse effects
- Humans
- Lung Neoplasms -- drug therapy
- MAP Kinase Signaling System -- drug effects
- Mechanistic Target of Rapamycin Complex 1 -- metabolism
- Mice, SCID
- Mutation -- genetics
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Mas
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Sulfonamides -- adverse effects
- Treatment Outcome
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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