CRISPR/Cas9 β-globin gene targeting in human haematopoietic stem cells. [electronic resource]
Producer: 20170321Description: 384-389 p. digitalISSN:- 1476-4687
- Alleles
- Anemia, Sickle Cell -- genetics
- Animals
- Antigens, CD34 -- metabolism
- CRISPR-Associated Proteins -- metabolism
- CRISPR-Cas Systems -- genetics
- Cell Differentiation
- Cell Lineage
- Cell Separation
- Dependovirus -- genetics
- Erythrocytes
- Female
- Flow Cytometry
- Gene Editing -- methods
- Gene Targeting
- Genes, Reporter
- Genetic Therapy -- methods
- Hematopoietic Stem Cells -- metabolism
- Homologous Recombination
- Humans
- Magnets
- Mice, Inbred NOD
- Mice, SCID
- Microspheres
- Mutation
- RNA, Messenger -- biosynthesis
- beta-Globins -- genetics
- beta-Thalassemia -- genetics
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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