Evaluation of the Tobacco Heating System 2.2. Part 6: 90-day OECD 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of a mentholated version compared with mentholated and non-mentholated cigarette smoke. [electronic resource]
Producer: 20170313Description: S93-S122 p. digitalISSN:- 1096-0295
- Aerosols
- Animals
- Biomarkers -- blood
- Computational Biology
- Consumer Product Safety
- Dose-Response Relationship, Drug
- Electronic Nicotine Delivery Systems -- adverse effects
- Equipment Design
- Female
- Gene Expression Profiling
- Gene Expression Regulation -- drug effects
- Genetic Markers
- Genomics
- Harm Reduction
- Hot Temperature
- Humans
- Inhalation Exposure -- adverse effects
- Lung -- drug effects
- Male
- Menthol -- analysis
- Nasal Mucosa -- drug effects
- Rats, Sprague-Dawley
- Risk Assessment
- Smoke -- adverse effects
- Smoking -- adverse effects
- Time Factors
- Tobacco Industry
- Tobacco Products -- analysis
- Toxicity Tests -- methods
- Toxicogenetics
- Transcriptome -- drug effects
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Publication Type: Comparative Study; Journal Article
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