Prostate cancer-associated mutation in SPOP impairs its ability to target Cdc20 for poly-ubiquitination and degradation. [electronic resource]
Producer: 20170808Description: 207-214 p. digitalISSN:- 1872-7980
- Antineoplastic Agents -- pharmacology
- Carbamates -- pharmacology
- Cdc20 Proteins -- antagonists & inhibitors
- Cullin Proteins -- antagonists & inhibitors
- Cyclopentanes -- pharmacology
- Diamines -- pharmacology
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- pharmacology
- HeLa Cells
- Humans
- Male
- Molecular Targeted Therapy
- Mutation
- Nuclear Proteins -- genetics
- Prostatic Neoplasms -- drug therapy
- Protein Interaction Domains and Motifs
- Proteolysis
- Pyrimidines -- pharmacology
- Repressor Proteins -- genetics
- Time Factors
- Transfection
- Ubiquitination
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Publication Type: Journal Article
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