25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome. [electronic resource]
Producer: 20180823Description: 13129 p. digitalISSN:- 2041-1723
- ATP Binding Cassette Transporter, Subfamily D, Member 1 -- genetics
- Adrenoleukodystrophy -- chemically induced
- Animals
- Corpus Callosum -- drug effects
- Fibroblasts -- drug effects
- Gene Expression
- Hydroxycholesterols -- metabolism
- Induced Pluripotent Stem Cells -- drug effects
- Inflammasomes -- drug effects
- Inflammation
- Injections, Intraventricular
- Liver X Receptors -- genetics
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Knockout
- NLR Family, Pyrin Domain-Containing 3 Protein -- agonists
- Oligodendroglia -- drug effects
- Primary Cell Culture
- Reactive Oxygen Species -- metabolism
- Stereotaxic Techniques
- Steroid Hydroxylases -- deficiency
- White Matter -- drug effects
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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