eEF2K inhibition blocks Aβ42 neurotoxicity by promoting an NRF2 antioxidant response. [electronic resource]
Producer: 20170922Description: 101-119 p. digitalISSN:- 1432-0533
- Alzheimer Disease -- enzymology
- Amyloid beta-Peptides -- genetics
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Cell Survival -- drug effects
- Cells, Cultured
- Elongation Factor 2 Kinase -- antagonists & inhibitors
- Enzyme Inhibitors -- pharmacology
- Female
- Frontal Lobe -- drug effects
- Hippocampus -- drug effects
- Humans
- Kelch-Like ECH-Associated Protein 1 -- metabolism
- Male
- NF-E2-Related Factor 2 -- metabolism
- Neurons -- drug effects
- Neuroprotective Agents -- pharmacology
- Oxidative Stress -- drug effects
- Peptide Fragments -- genetics
- Reactive Oxygen Species
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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