Discovery of Indazoles as Potent, Orally Active Dual Neurokinin 1 Receptor Antagonists and Serotonin Transporter Inhibitors for the Treatment of Depression. [electronic resource]
Producer: 20171020Description: 1635-1640 p. digitalISSN:- 1948-7193
- Administration, Oral
- Animals
- Antidepressive Agents -- chemical synthesis
- Depressive Disorder -- drug therapy
- Disease Models, Animal
- Dose-Response Relationship, Drug
- Drug Discovery
- Drug Evaluation, Preclinical
- Gerbillinae
- Humans
- Indazoles -- chemical synthesis
- Mice
- Molecular Structure
- Neurokinin-1 Receptor Antagonists -- chemical synthesis
- Rats
- Receptors, Neurokinin-1 -- metabolism
- Serotonin Plasma Membrane Transport Proteins -- metabolism
- Selective Serotonin Reuptake Inhibitors -- chemical synthesis
- Structure-Activity Relationship
- Transcriptional Regulator ERG -- metabolism
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Publication Type: Journal Article
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