Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death. [electronic resource]
Producer: 20180223Description: 78883-78895 p. digitalISSN:- 1949-2553
- Active Transport, Cell Nucleus -- drug effects
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Bone Neoplasms -- drug therapy
- Bortezomib -- pharmacology
- Cell Death -- drug effects
- Cell Line, Tumor
- Cell Nucleus -- drug effects
- Dose-Response Relationship, Drug
- Drug Resistance, Neoplasm
- Drug Synergism
- Female
- Fibrosarcoma -- drug therapy
- Humans
- Hydrazines -- pharmacology
- Karyopherins -- antagonists & inhibitors
- Mice, Inbred ICR
- Mice, SCID
- NF-KappaB Inhibitor alpha -- genetics
- NF-kappa B -- genetics
- Osteosarcoma -- drug therapy
- Phosphorylation
- Proteasome Endopeptidase Complex -- metabolism
- Proteasome Inhibitors -- pharmacology
- Proteolysis
- RNA Interference
- Receptors, Cytoplasmic and Nuclear -- antagonists & inhibitors
- Signal Transduction -- drug effects
- Time Factors
- Transcription Factor RelA -- genetics
- Transfection
- Triazoles -- pharmacology
- Exportin 1 Protein
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Publication Type: Comparative Study; Journal Article
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