NQO1 and CYP450 reductase decrease the systemic exposure of rifampicin-quinone and mediate its redox cycle in rats. [electronic resource]
Producer: 20170727Description: 17-23 p. digitalISSN:- 1873-264X
- Animals
- Calibration
- Chromatography, Liquid
- Cytochrome P-450 Enzyme System -- metabolism
- Hep G2 Cells
- Humans
- Limit of Detection
- Male
- Mass Spectrometry
- NAD(P)H Dehydrogenase (Quinone) -- metabolism
- Oxidation-Reduction
- Quality Control
- Quinones -- chemistry
- Rats
- Rats, Sprague-Dawley
- Reactive Oxygen Species -- metabolism
- Reproducibility of Results
- Rifampin -- analogs & derivatives
- Time Factors
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Publication Type: Journal Article
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