Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab. [electronic resource]
Producer: 20170731Description: 39-49 p. digitalISSN:- 1872-7980
- AMP-Activated Protein Kinases -- metabolism
- Acetyl-CoA Carboxylase -- antagonists & inhibitors
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antineoplastic Agents -- pharmacology
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Carcinoma, Squamous Cell -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Survival -- drug effects
- Cetuximab -- pharmacology
- Drug Resistance, Neoplasm
- Enzyme Inhibitors -- pharmacology
- Female
- Glycolysis -- drug effects
- Head and Neck Neoplasms -- drug therapy
- Humans
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Lipolysis -- drug effects
- Male
- Mice, Nude
- Middle Aged
- Mutation
- Phosphorylation
- RNA Interference
- Signal Transduction -- drug effects
- Squamous Cell Carcinoma of Head and Neck
- Time Factors
- Transfection
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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