Inhibition of ATR-dependent feedback activation of Chk1 sensitises cancer cells to Chk1 inhibitor monotherapy. [electronic resource]
Producer: 20170724Description: 41-52 p. digitalISSN:- 1872-7980
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Ataxia Telangiectasia Mutated Proteins -- antagonists & inhibitors
- Bone Neoplasms -- drug therapy
- Cell Proliferation -- drug effects
- Checkpoint Kinase 1 -- antagonists & inhibitors
- Colorectal Neoplasms -- drug therapy
- DNA Damage
- DNA-Activated Protein Kinase -- antagonists & inhibitors
- Dose-Response Relationship, Drug
- HT29 Cells
- Histones -- metabolism
- Humans
- Indoles -- pharmacology
- Isoxazoles -- pharmacology
- Molecular Targeted Therapy
- Nuclear Proteins -- antagonists & inhibitors
- Osteosarcoma -- drug therapy
- Protein Kinase Inhibitors -- pharmacology
- Pyrazines -- pharmacology
- Pyridones -- pharmacology
- Signal Transduction -- drug effects
- Time Factors
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Publication Type: Journal Article
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