Pan-Raf co-operates with PI3K-dependent signalling and critically contributes to myeloma cell survival independently of mutated RAS. [electronic resource]
Producer: 20171009Description: 922-933 p. digitalISSN:- 1476-5551
- Apoptosis -- genetics
- Cell Line, Tumor
- Cell Survival -- genetics
- Drug Resistance, Neoplasm
- Enzyme Activation
- Gene Expression
- Gene Knockdown Techniques
- Humans
- Isoenzymes
- Lenalidomide
- MAP Kinase Signaling System -- drug effects
- Multiple Myeloma -- genetics
- Mutation
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphorylation -- drug effects
- Protein Binding
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- RNA Interference
- RNA, Small Interfering -- genetics
- Signal Transduction
- TOR Serine-Threonine Kinases -- metabolism
- Thalidomide -- analogs & derivatives
- ras Proteins -- genetics
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Publication Type: Journal Article
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