The immune modulatory peptide FhHDM-1 secreted by the helminth Fasciola hepatica prevents NLRP3 inflammasome activation by inhibiting endolysosomal acidification in macrophages. [electronic resource]
Producer: 20170829Description: 85-95 p. digitalISSN:- 1530-6860
- Animals
- Cathepsin B -- genetics
- Cytokines -- genetics
- Fasciola hepatica -- genetics
- Gene Expression Regulation -- physiology
- Helminth Proteins -- genetics
- Hydrogen-Ion Concentration
- Lysosomes -- metabolism
- Macrophages -- drug effects
- Mice
- Mice, Inbred BALB C
- NLR Family, Pyrin Domain-Containing 3 Protein -- genetics
- Silicon Dioxide -- toxicity
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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