PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2. [electronic resource]
Producer: 20170904Description: 1006-20 p. digitalISSN:- 1097-4164
- Acetyl-CoA Carboxylase -- antagonists & inhibitors
- Amino Acid Sequence
- Animals
- Cell Line, Tumor
- Fatty Acids -- metabolism
- Gene Expression Regulation, Neoplastic
- HEK293 Cells
- Humans
- Hydroxylation
- Hypoxia-Inducible Factor-Proline Dioxygenases -- chemistry
- K562 Cells
- Leukemia, Myeloid, Acute -- genetics
- Male
- Metabolic Networks and Pathways -- genetics
- Mice
- Mice, Inbred NOD
- Models, Molecular
- Neoplasm Transplantation
- Oxidation-Reduction
- Proline -- chemistry
- RNA, Small Interfering -- genetics
- Signal Transduction
- Structural Homology, Protein
- Survival Analysis
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.
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