Blocking downstream signaling pathways in the context of HDAC inhibition promotes apoptosis preferentially in cells harboring mutant Ras. [electronic resource]
Producer: 20180213Description: 69804-69815 p. digitalISSN:- 1949-2553
- Apoptosis -- drug effects
- Cell Line, Tumor
- Depsipeptides -- pharmacology
- Extracellular Signal-Regulated MAP Kinases -- antagonists & inhibitors
- Genes, ras
- Histone Deacetylase Inhibitors -- pharmacology
- Humans
- Mitogen-Activated Protein Kinase Kinases -- antagonists & inhibitors
- Mutation
- Phosphoinositide-3 Kinase Inhibitors
- Proto-Oncogene Proteins c-akt -- antagonists & inhibitors
- Signal Transduction -- drug effects
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Publication Type: Journal Article
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