TNIK inhibition abrogates colorectal cancer stemness. [electronic resource]
Producer: 20180917Description: 12586 p. digitalISSN:- 2041-1723
- Adenomatous Polyposis Coli Protein -- genetics
- Administration, Oral
- Aged
- Animals
- Azoxymethane -- toxicity
- Carcinogenesis -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Cell Transformation, Neoplastic -- pathology
- Colorectal Neoplasms -- chemically induced
- Crystallography, X-Ray
- Female
- Germinal Center Kinases
- Humans
- Imidazoles -- pharmacology
- Male
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Knockout
- Mice, Nude
- Middle Aged
- Mutation
- Neoplastic Stem Cells -- drug effects
- Protein Binding
- Protein Kinase Inhibitors -- pharmacology
- Protein Serine-Threonine Kinases -- antagonists & inhibitors
- Quinazolines -- pharmacology
- Recombinant Proteins -- genetics
- Ubiquitin-Protein Ligases
- Wnt Proteins -- metabolism
- Wnt Signaling Pathway -- drug effects
- Xenograft Model Antitumor Assays
- beta Catenin -- genetics
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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