Inactivation of TGFβ receptors in stem cells drives cutaneous squamous cell carcinoma. [electronic resource]
Producer: 20180911Description: 12493 p. digitalISSN:- 2041-1723
- Animals
- Antineoplastic Agents -- adverse effects
- Biopsy
- Carcinogenesis -- genetics
- Carcinoma, Squamous Cell -- chemically induced
- Cell Line, Tumor
- DNA Mutational Analysis -- methods
- Female
- Humans
- Indoles -- adverse effects
- Male
- Melanoma -- drug therapy
- Mice
- Mice, Inbred Strains
- Mutation
- Neoplasms, Experimental -- chemically induced
- Protein Serine-Threonine Kinases -- genetics
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Proto-Oncogene Proteins p21(ras) -- genetics
- Receptor, Transforming Growth Factor-beta Type I
- Receptor, Transforming Growth Factor-beta Type II
- Receptors, Transforming Growth Factor beta -- genetics
- Signal Transduction -- drug effects
- Skin Neoplasms -- chemically induced
- Stem Cells
- Sulfonamides -- adverse effects
- Transforming Growth Factor beta -- metabolism
- Tumor Suppressor Protein p53 -- genetics
- Vemurafenib
- Exome Sequencing
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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