Patients homozygous for DPYD c.1129-5923C>G/haplotype B3 have partial DPD deficiency and require a dose reduction when treated with fluoropyrimidines. [electronic resource]
Producer: 20170606Description: 875-80 p. digitalISSN:- 1432-0843
- Aged
- Antimetabolites, Antineoplastic -- administration & dosage
- Capecitabine -- administration & dosage
- DNA, Complementary -- genetics
- Dihydropyrimidine Dehydrogenase Deficiency -- genetics
- Dihydrouracil Dehydrogenase (NADP) -- genetics
- Female
- Fluorouracil -- administration & dosage
- Gene Expression
- Genetic Variation
- Genotype
- Haplotypes
- Humans
- Introns -- genetics
- Male
- Middle Aged
- Mutation -- genetics
- Neoplasms -- complications
- Precision Medicine
- Retrospective Studies
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Publication Type: Journal Article
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