Dual MET/EGFR therapy leads to complete response and resistance prevention in a MET-amplified gastroesophageal xenopatient cohort. [electronic resource]
Producer: 20170926Description: 1200-1210 p. digitalISSN:- 1476-5594
- Aged, 80 and over
- Animals
- Antineoplastic Combined Chemotherapy Protocols -- pharmacology
- Apoptosis -- drug effects
- Biomarkers, Tumor -- genetics
- Cell Proliferation -- drug effects
- Cetuximab -- administration & dosage
- Drug Resistance, Neoplasm -- genetics
- ErbB Receptors -- antagonists & inhibitors
- Esophageal Neoplasms -- drug therapy
- Esophagogastric Junction -- drug effects
- Gene Amplification
- Humans
- Lapatinib
- Male
- Mice
- Mice, Inbred NOD
- Mice, SCID
- Phosphorylation
- Proto-Oncogene Proteins c-met -- antagonists & inhibitors
- Quinazolines -- administration & dosage
- Signal Transduction
- Stomach Neoplasms -- drug therapy
- Tumor Cells, Cultured
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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