FTY720 (Fingolimod) Inhibits HIF1 and HIF2 Signaling, Promotes Vascular Remodeling, and Chemosensitizes in Renal Cell Carcinoma Animal Model. [electronic resource]
Producer: 20170615Description: 2465-2474 p. digitalISSN:- 1538-8514
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Basic Helix-Loop-Helix Transcription Factors -- genetics
- Carcinoma, Renal Cell -- drug therapy
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Disease Models, Animal
- Drug Resistance, Neoplasm
- Female
- Fingolimod Hydrochloride -- pharmacology
- Gene Expression
- Humans
- Hypoxia -- genetics
- Hypoxia-Inducible Factor 1, alpha Subunit -- genetics
- Lysophospholipids
- Mice
- Neovascularization, Pathologic -- drug therapy
- Oxygen Consumption
- Phosphotransferases (Alcohol Group Acceptor) -- metabolism
- Receptors, Lysosphingolipid -- metabolism
- Signal Transduction -- drug effects
- Sphingosine -- analogs & derivatives
- Vascular Endothelial Growth Factor A -- biosynthesis
- Vascular Remodeling -- drug effects
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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