Synthesis and biological evaluation of some novel triazole hybrids of curcumin mimics and their selective anticancer activity against breast and prostate cancer cell lines. [electronic resource]
Producer: 20170726Description: 4223-32 p. digitalISSN:- 1464-3405
- Antineoplastic Agents -- chemical synthesis
- Apoptosis -- drug effects
- Breast Neoplasms -- metabolism
- Cell Cycle Checkpoints -- drug effects
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Click Chemistry
- Curcumin -- chemistry
- Down-Regulation -- drug effects
- Drug Screening Assays, Antitumor
- Female
- HEK293 Cells
- Half-Life
- Humans
- Male
- Membrane Potential, Mitochondrial -- drug effects
- Proliferating Cell Nuclear Antigen -- metabolism
- Prostatic Neoplasms -- metabolism
- Proto-Oncogene Proteins c-akt -- metabolism
- Proto-Oncogene Proteins c-bcl-2 -- metabolism
- Triazoles -- chemistry
- bcl-2-Associated X Protein -- metabolism
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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