Debio 0617B Inhibits Growth of STAT3-Driven Solid Tumors through Combined Inhibition of JAK, SRC, and Class III/V Receptor Tyrosine Kinases. [electronic resource]
Producer: 20170615Description: 2334-2343 p. digitalISSN:- 1538-8514
- Animals
- Antineoplastic Agents -- chemistry
- Apoptosis -- drug effects
- Cell Line, Tumor
- Disease Models, Animal
- Drug Design
- Humans
- Janus Kinases -- antagonists & inhibitors
- Mice
- Molecular Conformation
- Molecular Docking Simulation
- Molecular Dynamics Simulation
- Neoplasm Metastasis
- Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- chemistry
- Receptor Protein-Tyrosine Kinases -- antagonists & inhibitors
- STAT3 Transcription Factor -- metabolism
- Signal Transduction -- drug effects
- Tumor Burden -- drug effects
- Xenograft Model Antitumor Assays
- src-Family Kinases -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't
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