A Nexus Consisting of Beta-Catenin and Stat3 Attenuates BRAF Inhibitor Efficacy and Mediates Acquired Resistance to Vemurafenib. [electronic resource]
Producer: 20170214Description: 132-149 p. digitalISSN:- 2352-3964
- Animals
- Antineoplastic Agents -- pharmacology
- Apoptosis -- drug effects
- Cell Cycle -- drug effects
- Cell Line, Tumor
- Cell Survival -- drug effects
- Disease Models, Animal
- Drug Resistance, Neoplasm -- genetics
- Gene Knockdown Techniques
- Humans
- Indoles -- pharmacology
- Melanoma -- drug therapy
- Mice
- Protein Kinase Inhibitors -- pharmacology
- Proto-Oncogene Proteins B-raf -- antagonists & inhibitors
- Resin Cements
- STAT3 Transcription Factor -- metabolism
- Sulfonamides -- pharmacology
- Vemurafenib
- Wnt Signaling Pathway -- drug effects
- Xenograft Model Antitumor Assays
- beta Catenin -- genetics
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Publication Type: Journal Article
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