SYD985, a Novel Duocarmycin-Based HER2-Targeting Antibody-Drug Conjugate, Shows Antitumor Activity in Uterine Serous Carcinoma with HER2/Neu Expression. [electronic resource]
Producer: 20170629Description: 1900-9 p. digitalISSN:- 1538-8514
- Adult
- Aged
- Aged, 80 and over
- Animals
- Antibody-Dependent Cell Cytotoxicity -- immunology
- Antineoplastic Agents -- chemistry
- Bystander Effect
- Cathepsin B -- genetics
- Cell Line, Tumor
- Cell Survival -- drug effects
- Class I Phosphatidylinositol 3-Kinases
- Cystadenocarcinoma, Serous -- drug therapy
- Disease Models, Animal
- Duocarmycins
- Female
- Gene Expression
- Humans
- Immunoconjugates -- chemistry
- Indoles -- chemistry
- Mice
- Middle Aged
- Mutation
- Phosphatidylinositol 3-Kinases -- genetics
- Pyrrolidinones -- chemistry
- Receptor, ErbB-2 -- antagonists & inhibitors
- Survival Analysis
- Uterine Neoplasms -- drug therapy
- Xenograft Model Antitumor Assays
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Publication Type: Journal Article
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